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Peer review Peer review information Nature Communications thanks Jing Yang, Vinayak Khodade and the other anonymous reviewer(s) for their contribution to the peer review of this work

cerevisiae aging, as mutating H3T11 to alanine clearly extends yeast chronological lifespan (Oh et al., 2018)

Step 5: Quality Control and Characterization Each batch undergoes rigorous physicochemical and functional characterization

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Nobiletin , a flavone found in citrus peels, exerted anti-inflammatory effects in TNBS-induced colitis through the downregulation of iNOS and COX-2 expression, restoring barrier function through the inhibition of the Akt-NF-B-MLCK pathway [111]